Portable neuroimaging and computational modeling approach to elucidate potential cognitive confounds in non-invasive stimulation of the motor cerebellum

I read with great interest the correspondence by Robert M. Hardwick, Amanda S. Therrien, and Elise Lesage describing cognitive confounds during non-invasive stimulation of the motor cerebellum [1]. Indeed, the high likelihood of cognitive effects of cerebellar transcranial stimulation is possible unless we optimize the electrode montage based on the cerebellar lobule-specific electric field distribution – see Fig. 1 adapted from Ref. [2]. Therefore, we augmented the freely available modeling pipelines for transcranial stimulation [3,4] with the ability to isolate cerebellar lobules based on Spatially Unbiased Infratentorial Template for the Cerebellum atlas [5] (Diedrichsen et al., 2009) that allowed optimization of lobule-specific electric fields distributions [6].

Abstract licence: CC BY-NC

1. 2.

   Functional gradients of the cerebellum · 2018

2. 5.

   Realistic volumetric-approach to simulate transcranial electric stimulation—ROAST—a fully automated open-source pipeline · 2019

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