Molecular genetic techniques for gains and losses of genomic material in a case of acute myeloid leukemia

A 67-year-old male presented with a four-week history of weakness.The complete blood count showed: hemoglobin: 5.1 g/dL, leukocytes 182.55 × 10 3 /L (23% blasts and 34% monocytes) and platelets: 31 × 10 9 /L.A bone marrow aspirate showed 50.4% of myeloid myeloperoxidase (MPO)-blast cells and 42.4% of dysplastic granulocytic-monocytic series, with alpha-naphthyl acetate esterase positivity in 30% of total nucleated cells.Flow cytometry identified two distinct aberrant blasts (CD4-CD7-CD11c-CD13-CD34-CD117-HLA-DR-cMPO + ) and myeloid/monocytic (CD14-CD33-CD35-HLA-DR-CD11b + ) populations.Karyotyping showed monosomy 7 and additional material in the long arm of chromosome 2

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