A review on quinoline hydrazone derivatives as a new class of potent antitubercular and anticancer agents

Tuberculosis (TB) and Cancer remains a global public health problem in recent years. There is an urgent need for the screening of new bioactive molecules with new targets and with a different mechanism of action. Among heterocyclic compounds, compounds with Quinoline core gained much importance in medicinal chemistry. Quinoline hydrazone scaffold plays an important role in anti-tuberculosis and anticancer drug development as their derivatives have shown outstanding results. This broad spectrum of biological and biochemical activities has been further assisted by the synthetic flexibility of quinoline, which permits the invention of a large number of structurally varied hydrazone derivatives and their metal complexes. In order to pave the way for future advanced research, there is a need to collect and analyze the latest information available so far in this promising area. In this review, we have compiled and discussed the published reports specifically on anti-tuberculosis and anticancer potential of quinoline hydrazone derivatives. It is hoped that this review will be helpful for researchers in developing a new view in the search for rational designs of more active and less toxic quinoline-based anti-TB and anticancer drugs. Keywords: Biological activity, Quinoline, Hydrazone, Cancer, Tuberculosis

Abstract licence: CC BY

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