The role of GPR56/ADGRG1 in health and disease
Abhishek Kumar Singh, Hsi-Hsien Lin
Biomedical Journal · 2021
doi:10.1016/j.bj.2021.04.012 (opens in a new tab)
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Abstract
GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.
Abstract licence: CC BY-NC-ND
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