P112 CENTRAL PULSE WAVE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS

Background: Arterial stiffness is known marker of poor cardiovascular prognosis. The aim if the study was to assess the incidence of valve calcification (VC) in patients with end- stage renal disease (ESRD) and its associations with clinical parameters of arterial stiffness. Methods: In 68 adults with ESRD on maintenance hemodialysis for >3 months (45.6% males, median age 58.3 (interquartile range (IQR) 54.6; 61.6) years, dialysis duration 62.7 (47.8; 77) months, echocardiography and applanation tonometry was performed. Results: Calcification of the aortic, mitral and both valves was revealed in 46 (67.6%), 34 (50%) and 33 (48.5%) of patients. 20 (29%) patients had no signs of VC. Patients with vs without AVC were older (65.1±9.5 vs 41.4±11,9 years, p < 0.001), had higher dialysis duration (51 (8; 252) vs 21 (10; 38) months, p < 0.01), lower peripheral diastolic blood pressure (DBP) (76±17 vs 84±12 mmHg, p < 0.05), central DBP (75±15 vs 82±11 mmHg, p < 0.05), reflected wave transit time (RWTT) (131±17 vs 137±15 ms, p < 0.05). Patients with vs without MVC were older (67.8±8.2 vs 47.9±13,5 years, p < 0.001), had higher dialysis duration (51 (34; 111) vs 36 (14; 57) months, p < 0.01), carotid-femoral pulse wave velocity (10.1±2.7 vs 8.9±3.5 m/s, p < 0.05), lower peripheral DBP (73±17 vs 84±14 mmHg, p < 0.01), central DBP (72±13 vs 83±13 mmHg, p < 0.001), higher central pulse pressure (52±13 vs 45±16 mmHg, p < 0.05), lower RWTT (133 (120; 130) vs 135 (132; 142) ms, p < 0.05). Conclusion: High prevalence of VC (71%) was revealed in patients with ESRD on maintenance hemodialysis. Patients with vs without VC were older, had higher duration of dialysis and more pronounced arterial stiffness.

Abstract licence: CC BY

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