P3.25 THE EFFECT OF DIASTOLIC ASYMPTOTIC PRESSURE ON THE RESERVOIR PRESSURE IN HUMAN

Background: Arterial diastolic asymptotic pressure (P∞) is the pressure reached when the heart stops beating. Determination of the reservoir pressure (Pr) requires a value of P∞ which was previously assumed (1), calculated (2) and measured (3, 4) as 0, 35, 14, 24 mmHg respectively. The effects of varying P∞ on the determination of Pr is the primary objective of this study. Methods: Pr was calculated from the carotid pressure of 2003 subjects of the Asklepios study (a) using a free fitting algorithm for the determination of P∞ and (b) setting P∞ to the average of the experimental values (19 mmHg). Results: The reservoir pulse pressure (PPr) is higher using the free fitting method than setting P∞ (Fig1). PPr increases significantly with age and is higher in male than female in both cases. Conclusions: PPr is generally higher in male than female and its absolute value is dependant on the value of P∞. Higher values of PPr suggests deterioration of the arterial buffering function with age. Figure 1.Changes of PPr with age and gender using the free fitting algorithm (a) and 19mmHg (b).

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