A potential role for integrins in host cell entry by SARS-CoV-2

Abstract

• Integrin may act as an alternative receptor for SARS-CoV-2 and could be implicated in its transmission and pathology. • The spike protein of SARS-CoV-2 acquired a RGD motif known to bind integrins. This motif is absent from other coronaviruses. • The integrin-binding motif is present at the surface of the spike protein, close to the ACE2 receptor-binding region. • Integrin binding may be a promising therapeutics target, and should be tested experimentally.

Cited by papers we hold 8

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• RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field · 2021
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• COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts · 2021
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• Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic · 2021
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• Inhibiting Extracellular Vesicle Trafficking as Antiviral Approach to Corona Virus Disease 2019 Infection · 2020
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• Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor · 2020
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• Impact of COVID-19 on the thyroid gland: an update · 2020
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