Massive periorbital edema following hematopoietic stem cell transplantation
Jeannette Y. Stallworth, Jonathan C. Horton
American Journal of Ophthalmology Case Reports · 2022
doi:10.1016/j.ajoc.2022.101559 (opens in a new tab)
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Abstract
Purpose: To describe a case of severe, bilateral periorbital edema after hematopoietic stem cell transplantation. Observations: A three-year old girl with metastatic neuroblastoma underwent the second of two tandem autologous peripheral blood stem cell transplants, complicated by engraftment syndrome. On post-engraftment day 11, she developed acute onset of severe periorbital edema. She was soon thereafter diagnosed with transplant-associated thrombotic microangiopathy with significant volume overload requiring treatment with eculizumab and etanercept. Periorbital edema resolved after four days with concurrent treatment of her underlying condition. Conclusions and Importance: We report an ocular manifestation related to complications of hematopoietic stem cell transplantation. This highlights a non-infectious etiology of eyelid swelling in the post-transplant, immunocompromised population.
Abstract licence: CC BY-NC
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