Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

Abstract

Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replication, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells. Thus, multiple therapeutic strategies based on iron deprivation have been developed in cancer therapy. During the past few years, our understanding of genetic association and molecular mechanisms between iron and tumorigenesis has expanded enormously. In this review, we briefly summarize iron homeostasis in mammals, and discuss recent progresses in understanding the aberrant iron metabolism in numerous cancer types, with a focus on studies revealing altered signal transduction in cancer cells.

Cited by papers we hold 5

• Ferroptosis as a potential target for cancer therapy · 2023
  No notice
• Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response · 2022
  No notice
• Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology · 2020
  No notice
• Iron Metabolism in Cancer · 2018
  No notice
• Iron Homeostasis in Health and Disease · 2016
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.