The hierarchy quorum sensing network in Pseudomonas aeruginosa

Abstract

Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. Quorum sensing (QS), a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacterial population changes but also could react to environmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.

Cited by papers we hold 23

• Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria · 2022
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• Spontaneous quorum-sensing hierarchy reprogramming in Pseudomonas aeruginosa laboratory strain PAO1 · 2022
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• Microevolution of the mexT and lasR Reinforces the Bias of Quorum Sensing System in Laboratory Strains of Pseudomonas aeruginosa PAO1 · 2022
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• Pseudomonas aeruginosa reference strains PAO1 and PA14: A genomic, phenotypic, and therapeutic review · 2022
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• Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review · 2022
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• Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics · 2022
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• It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant Pseudomonas aeruginosa · 2021
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• Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors · 2021
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• Biofilms by bacterial human pathogens: Clinical relevance - development, composition and regulation - therapeutical strategies · 2021
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• Pseudomonas aeruginosa Biofilms · 2020
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• Regulatory Mechanisms and Promising Applications of Quorum Sensing-Inhibiting Agents in Control of Bacterial Biofilm Formation · 2020
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• Defeating Antibiotic-Resistant Bacteria: Exploring Alternative Therapies for a Post-Antibiotic Era · 2020
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• Recent Advances in Anti-virulence Therapeutic Strategies With a Focus on Dismantling Bacterial Membrane Microdomains, Toxin Neutralization, Quorum-Sensing Interference and Biofilm Inhibition · 2019
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• Natural quorum sensing inhibitors effectively downregulate gene expression of Pseudomonas aeruginosa virulence factors · 2019
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• An integrated genomic regulatory network of virulence-related transcriptional factors in Pseudomonas aeruginosa · 2019
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• Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective · 2018
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• The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore · 2018
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• The Type VI Secretion System: A Dynamic System for Bacterial Communication? · 2017
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• Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence · 2017
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• The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer · 2017
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and 3 more

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