Skip to content
naulon

No retraction, correction or concern found when last checked on Oct 17, 2026.

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

Claire C. Chen, Linan Liu, Fengxia Ma and 12 more

Cellular and Molecular Bioengineering · 2016

doi:10.1007/s12195-016-0458-3

References 77

  1. 1.

    Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006;7:41-53.

    Not in our library10.1038/nrn1824

  2. 2.

    Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341-345.

    Not in our library10.1038/nbt.1807

  3. 3.

    Andreone BJ, Lacoste B, Gu C. Neuronal and vascular interactions. Annu Rev Neurosci. 2015;38:25-46.

    Not in our library10.1146/annurev-neuro-071714-033835

  4. 4.

    Banks WA. From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery. Nat Rev Drug Discov. 2016.

    Not in our library10.1038/nrd.2015.21

  5. 5.

    Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, Lu M, Zhu Z, Chopp M. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003;92:692-699.

    Not in our library10.1161/01.res.0000063425.51108.8d

  6. 6.

    Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol. 2014;30:255-289.

    Not in our library10.1146/annurev-cellbio-101512-122326

  7. 7.

    Deli MA, Descamps L, Dehouck MP, Cecchelli R, Joo F, Abraham CS, Torpier G. Exposure of tumor necrosis factor-alpha to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin. J Neurosci Res. 1995;41:717-726.

    Not in our library10.1002/jnr.490410602

  8. 8.

    Dendrou CA, Fugger L, Friese MA. Immunopathology of multiple sclerosis. Nat Rev Immunol. 2015;15:545-558.

    Not in our library10.1038/nri3871

  9. 9.

    Descamps L, Cecchelli R, Torpier G. Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers. J Neuroimmunol. 1997;74:173-184.

    Not in our library10.1016/s0165-5728(96)00226-3

  10. 10.

    Dobson PD, Kell DB. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov. 2008;7:205-220.

    Not in our library10.1038/nrd2438

  11. 11.

    Dulamea AO. The potential use of mesenchymal stem cells in stroke therapy-From bench to bedside. Journal of the Neurological Sciences. 2015;352:1-11.

    Not in our library10.1016/j.jns.2015.03.014

  12. 12.

    El-Andaloussi S, Mager I, Breakefield XO, Wood MJ. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013;12:347-357.

    Not in our library10.1038/nrd3978

  13. 13.

    Etame AB, Diaz RJ, Smith CA, Mainprize TG, Hynynen K, Rutka JT. Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology. Neurosurg Focus. 2012;32:E3.

    Not in our library10.3171/2011.10.focus11252

  14. 14.

    Faille D, El-Assaad F, Mitchell AJ, Alessi MC, Chimini G, Fusai T, Grau GE, Combes V. Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells. J Cell Mol Med. 2012;16:1731-1738.

    Not in our library10.1111/j.1582-4934.2011.01434.x

  15. 15.

    Fischer S, Wiesnet M, Marti HH, Renz D, Schaper W. Simultaneous activation of several second messengers in hypoxia-induced hyperpermeability of brain derived endothelial cells. J Cell Physiol. 2004;198:359-369.

    Not in our library10.1002/jcp.10417

  16. 16.

    Fruhbeis C, Frohlich D, Kramer-Albers EM. Emerging roles of exosomes in neuron-glia communication. Front Physiol. 2012;3:119.

    Not in our library10.3389/fphys.2012.00119

  17. 17.

    Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol Dis. 2010;37:48-57.

    Not in our library10.1016/j.nbd.2009.07.028

  18. 18.
  19. 19.

    Hsu J, Rappaport J, Muro S. Specific binding, uptake, and transport of ICAM-1-targeted nanocarriers across endothelial and subendothelial cell components of the blood-brain barrier. Pharm Res. 2014;31:1855-1866.

    Not in our library10.1007/s11095-013-1289-8

  20. 20.

    Imai T, Takahashi Y, Nishikawa M, Kato K, Morishita M, Yamashita T, Matsumoto A, Charoenviriyakul C, Takakura Y. Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice. J Extracell Vesicles. 2015;4:26238.

    Not in our library10.3402/jev.v4.26238

  21. 21.

    Kalani A, Tyagi A, Tyagi N. Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol. 2014;49:590-600.

    Not in our library10.1007/s12035-013-8544-1

  22. 22.

    Komarova Y, Malik AB. Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol. 2010;72:463-493.

    Not in our library10.1146/annurev-physiol-021909-135833

  23. 23.

    Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu. Rev. Physiol. 2015;77:13-27.

    Not in our library10.1146/annurev-physiol-021014-071641

  24. 24.

    Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire CA, Chen JW, Tannous BA, Breakefield XO. Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter. Acs Nano. 2014;8:483-494.

    Not in our library10.1021/nn404945r

  25. 25.

    Lasser C. Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle. Expert Opin. Biol. Ther. 2015;15:103-117.

    Not in our library10.1517/14712598.2015.977250

  26. 26.

    Lasser C, O’Neil SE, Ekerljung L, Ekstrom K, Sjostrand M, Lotvall J. RNA-containing exosomes in human nasal secretions. Am J Rhinol Allergy. 2011;25:89-93.

    Not in our library10.2500/ajra.2011.25.3573

  27. 27.

    Lee CC, MacKay JA, Frechet JM, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol. 2005;23:1517-1526.

    Not in our library10.1038/nbt1171

  28. 28.

    Lee RH, Pulin AA, Seo MJ, Kota DJ, Ylostalo J, Larson BL, Semprun-Prieto L, Delafontaine P, Prockop DJ. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell. 2009;5:54-63.

    Not in our library10.1016/j.stem.2009.05.003

  29. 29.

    Liao W, Pham V, Liu L, Riazifar M, Pone EJ, Zhang SX, Ma F, Lu M, Walsh CM, Zhao W. Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials. 2016;77:87-97.

    Not in our library10.1016/j.biomaterials.2015.11.005

  30. 30.

    Liu L, Eckert MA, Riazifar H, Kang DK, Agalliu D, Zhao W. From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier? Stem Cells Int. 2013;2013:435093.

    Not in our library10.1155/2013/435093

  31. 31.

    Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Stem Cell Res Ther. 2015;6:181.

    Not in our library10.1186/s13287-015-0151-9

  32. 32.

    Manders EMM, Verbeek FJ, Aten JA. Measurement of Colocalization of Objects in Dual-Color Confocal Images. Journal of Microscopy-Oxford. 1993;169:375-382.

    Not in our library10.1111/j.1365-2818.1993.tb03313.x

  33. 33.

    Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73:1907-1920.

    Not in our library10.1016/j.jprot.2010.06.006

  34. 34.

    Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014;3.

    Not in our library10.3402/jev.v3.24641

  35. 35.

    Obermeier B, Daneman R, Ransohoff RM. Development, maintenance and disruption of the blood-brain barrier. Nat Med. 2013;19:1584-1596.

    Not in our library10.1038/nm.3407

  36. 36.

    Ohno S, Takanashi M, Sudo K, Ueda S, Ishikawa A, Matsuyama N, Fujita K, Mizutani T, Ohgi T, Ochiya T, Gotoh N, Kuroda M. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther. 2013;21:185-191.

    Not in our library10.1038/mt.2012.180

  37. 37.

    Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2010;12(supp 1– 13):19-30.

    Not in our library10.1038/ncb2000

  38. 38.

    Pardridge WM. Targeted delivery of protein and gene medicines through the blood-brain barrier. Clin Pharmacol Ther. 2015;97:347-361.

    Not in our library10.1002/cpt.18

  39. 39.

    Pardridge WM. Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery. Expert Opin Ther Targets. 2015;19:1059-1072.

    Not in our library10.1517/14728222.2015.1042364

  40. 40.

    Pardridge WM. Drug transport across the blood-brain barrier. J Cereb Blood Flow Metab. 2012;32:1959-1972.

    Not in our library10.1038/jcbfm.2012.126

All 77 references

Cited by papers we hold 29

and 9 more

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.