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Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Xin Zou, Ke Chen, Jiawei Zou and 3 more

Frontiers of Medicine · 2020 · CC BY

doi:10.1007/s11684-020-0754-0

Abstract

Electronic Supplementary Material. Supplementary material is available for this article at 10.1007/s11684-020-0754-0 and is accessible for authorized users.

References 19

  1. 1.

    WHO. Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov) (accessed Janaury 30, 2020)

    Not in our library

  2. 2.

    Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, Zhong W, Hao P. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Science China Life Sciences. 2020;63(3):457-460.

    Not in our library10.1007/s11427-020-1637-5

  3. 3.
    A pneumonia outbreak associated with a new coronavirus of probable bat origin · 2020
    No notice
  4. 4.

    Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis. Am J Respir Crit Care Med. 2019;199(12):1517-1536.

    Not in our library10.1164/rccm.201712-2410oc

  5. 5.
    Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures · 2019
    No notice
  6. 6.
    Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart · 2019
    Not checked
  7. 7.
    scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation · 2019
    No notice
  8. 8.

    Zhang P, Yang M, Zhang Y, Xiao S, Lai X, Tan A, Du S, Li S. Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer. Cell Rep. 2019;27(6):1934-1947.

    Not in our library10.1016/j.celrep.2019.04.052

  9. 9.
    Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations · 2018
    No notice
  10. 10.

    Martin JC, Chang C, Boschetti G, Ungaro R, Giri M, Grout JA, Gettler K, Chuang LS, Nayar S, Greenstein AJ, Dubinsky M, Walker L, Leader A, Fine JS, Whitehurst CE, Mbow ML, Kugathasan S, Denson LA, Hyams JS, Friedman JR, Desai PT, Ko HM, Laface I, Akturk G, Schadt EE, Salmon H, Gnjatic S, Rahman AH, Merad M, Cho JH, Kenigsberg E. Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy. Cell. 2019;178(6):1493-1508.

    Not in our library10.1016/j.cell.2019.08.008

  11. 11.

    Wu H, Malone AF, Donnelly EL, Kirita Y, Uchimura K, Ramakrishnan SM, Gaut JP, Humphreys BD. Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response. J Am Soc Nephrol. 2018;29(8):2069-2080.

    Not in our library10.1681/asn.2018020125

  12. 12.

    Yu Z, Liao J, Chen Y, Zou C, Zhang H, Cheng J, Liu D, Li T, Zhang Q, Li J, Yang X, Ye Y, Huang Z, Long X, Yang R, Mo Z. Single-cell transcriptomic map of the human and mouse bladders. J Am Soc Nephrol. 2019;30(11):2159-2176.

    Not in our library10.1681/asn.2019040335

  13. 13.

    Becht E, McInnes L, Healy J, Dutertre CA, Kwok IWH, Ng LG, Ginhoux F, Newell EW. Dimensionality reduction for visualizing single-cell data using UMAP. Nat Biotechnol. 2019;37:38-44.

    Not in our library10.1038/nbt.4314

  14. 14.

    Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004;203(2):631-637.

    Not in our library10.1002/path.1570

  15. 15.

    Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417(6891):822-828.

    Not in our library10.1038/nature00786

  16. 16.

    Kowalczuk S, Bröer A, Tietze N, Vanslambrouck JM, Rasko JEJ, Bröer S. A protein complex in the brush-border membrane explains a Hartnup disorder allele. FASEB J. 2008;22(8):2880-2887.

    Not in our library10.1096/fj.08-107300

  17. 17.

    Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res. 2000;87(5):E1-E9.

    Not in our library10.1161/01.res.87.5.e1

  18. 18.

    Harmer D, Gilbert M, Borman R, Clark KL. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett. 2002;532(1–2):107-110.

    Not in our library10.1016/s0014-5793(02)03640-2

  19. 19.

    Burrell LM, Risvanis J, Kubota E, Dean RG, MacDonald PS, Lu S, Tikellis C, Grant SL, Lew RA, Smith AI, Cooper ME, Johnston CI. Myocardial infarction increases ACE2 expression in rat and humans. Eur Heart J. 2005;26(4):369-375.

    Not in our library10.1093/eurheartj/ehi114

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