Common and unique features of viral RNA-dependent polymerases

Abstract

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

Cited by papers we hold 5

• Genomic insights into host-associated variants and transmission features of a ToBRFV isolate from Mexico · 2025
  Not checked
• Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny · 2022
  No notice
• Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19 · 2021
  No notice
• Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir · 2020
  No notice
• RNA Dependent RNA Polymerases: Insights from Structure, Function and Evolution · 2018
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.