Chromosomally integrated human herpesvirus 6: questions and answers

Abstract

SUMMARY Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV‐6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV‐6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV‐6 due to cell lysis and release of cellular DNA. High HHV‐6 DNA loads associated with ciHHV‐6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV‐6 may be at increased risk for bacterial infection and graft rejection. ciHHV‐6 can be induced to a state of active viral replication in vitro . It is not known whether ciHHV‐6 individuals are put at clinical risk by the use of drugs that have been associated with HHV‐6 reactivation in vivo or in vitro . Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV‐6. Little is known about whether individuals with ciHHV‐6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV‐6 in disease. Copyright © 2011 John Wiley & Sons, Ltd.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 87

1. 1.

   Clark DA, Ward KN. Importance of chromosomally integrated HHV-6A and -6B in the diagnosis of active HHV-6 infection. Herpes. 2008;15(2):28-32.

   Not in our library

2. 2.

   Yamanishi K, Mori M, Pellett PE, David PMH, Knipe M. Human herpesvirus 6 and 7. Fields Virology. 2007.

   Not in our library

3. 3.

   Morissette G, Flamand L. Herpesviruses and chromosomal integration. Journal of Virology. 2010;84(23):12100-12109.

   Not in our library10.1128/jvi.01169-10

4. 4.

   Arbuckle JH, Medveczky PG. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes Infect. 2011.

   Not in our library10.1016/j.micinf.2011.03.006

5. 5.

   Pellett PE, T.G., F.G., Versalovic KCC, Jorgensen JH, Landry ML, Warnock DW. Human herpesviruses 6, 7, and 8., in Manual of Clinical Microbiology. 2011.

   Not in our library

6. 6.

   Lee SO, Brown RA, Razonable RR. Clinical significance of pretransplant chromosomally integrated human herpesvirus-6 in liver transplant recipients. Transplantation. 2011;92(2):224-229.

   Not in our library10.1097/tp.0b013e318222444a

7. 7.

   Yamashita N, Morishima T. HHV-6 and seizures. Herpes. 2005;12(2):46-49.

   Not in our library

8. 8.

   Ichiyama T, et al. Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection. Brain & Development. 2009;31(10):731-738.

   Not in our library10.1016/j.braindev.2008.11.005

9. 9.

   Seeley WW, Marty FM, Holmes TM, et al. Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology. 2007;69(2):156-165.

   Not in our library10.1212/01.wnl.0000265591.10200.d7

10. 10.

    Gorniak RJ, Young GS, Wiese DE, Marty FM, Schwartz RB. MR imaging of human herpesvirus-6-associated encephalitis in 4 patients with anterograde amnesia after allogeneic hematopoietic stem-cell transplantation. AJNR. American Journal of Neuroradiology. 2006;27(4):887-891.

    Not in our library

11. 11.

    Bollen AE, Wartan AN, Krikke AP, Haaxma-Reiche H. Amnestic syndrome after lung transplantation by human herpes virus-6 encephalitis. Journal of Neurology. 2001;248(7):619-620.

    Not in our library10.1007/s004150170142

12. 12.

    Zerr DM, Fann JR, Breiger D, et al. HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients. Blood. 2011;117(19):5243-5249.

    Not in our library10.1182/blood-2010-10-316083

13. 13.

    Maric I, Bryant R, Abu-Asab M, et al. Human herpesvirus-6-associated acute lymphadenitis in immunocompetent adults. Modern Pathology. 2004;17(11):1427-1433.

    Not in our library10.1038/modpathol.3800179

14. 14.

    Revest M, Minjolle S, Veyer D, Lagathu G, Michelet C, Colimon R. Detection of HHV-6 in over a thousand samples: new types of infection revealed by an analysis of positive results. Journal of Clinical Virology. 2011;51(1):20-24.

    Not in our library10.1016/j.jcv.2011.02.001

15. 15.

    Lamoth F, Jayet PY, Aubert JD, et al. Case report: human herpesvirus 6 reactivation associated with colitis in a lung transplant recipient. Journal of Medical Virology. 2008;80(10):1804-1807.

    Not in our library10.1002/jmv.21268

16. 16.

    Amo K, Tanaka-Taya K, Inagi R, et al. Human herpesvirus 6B infection of the large intestine of patients with diarrhea. Clinical Infectious Diseases. 2003;36(1):120-123.

    Not in our library10.1086/345464

17. 17.

    Chevret L, Boutolleau D, Halimi-Idri N, et al. Human herpesvirus-6 infection: a prospective study evaluating HHV-6 DNA levels in liver from children with acute liver failure. Journal of Medical Virology. 2008;80(6):1051-1057.

    Not in our library10.1002/jmv.21143

18. 18.

    Yoshikawa T. Human herpesvirus 6 causes hepatitis in transplant recipients. Internal Medicine. 2006;45(7):417-418.

    Not in our library10.2169/internalmedicine.45.0147

19. 19.

    Peppercorn AF, Miller MB, Fitzgerald D, Weber DJ, Groben PA, Cairns BA. High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases. Journal of Burn Care & Research. 2010;31(2):365-368.

    Not in our library10.1097/bcr.0b013e3181d0f48b

20. 20.

    Chapenko S, Folkmane I, Ziedina I, et al. Association of HHV-6 and HHV-7 reactivation with the development of chronic allograft nephropathy. Journal of Clinical Virology. 2009;46(1):29-32.

    Not in our library10.1016/j.jcv.2009.05.018

21. 21.

    Tohyama M, Hashimoto K, Yasukawa M, et al. Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome. British Journal of Dermatology. 2007;157(5):934-940.

    Not in our library10.1111/j.1365-2133.2007.08167.x

22. 22.

    Marabelle A, Bergeron C, Billaud G, Mekki Y, Girard S. Hemophagocytic syndrome revealing primary HHV-6 infection. Journal de Pediatria. 2010;157(3):511.

    Not in our library10.1016/j.jpeds.2010.02.064

23. 23.

    Dharancy S, Crombe V, Copin MC, et al. Fatal hemophagocytic syndrome related to human herpesvirus-6 reinfection following liver transplantation: a case report. Transplantation Proceedings. 2008;40(10):3791-3793.

    Not in our library10.1016/j.transproceed.2008.05.083

24. 24.

    Kuhl U, Pauschinger M, Noutsias M, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with " idiopathic" left ventricular dysfunction. Circulation. 2005;111(7):887-893.

    Not in our library10.1161/01.cir.0000155616.07901.35

25. 25.

    Leveque N, Boulagnon C, Brasselet C, et al. A fatal case of human herpesvirus 6 chronic myocarditis in an immunocompetent adult. Journal of Clinical Virology. 2011.

    Not in our library10.1016/j.jcv.2011.06.017

26. 26.

    Mahrholdt H, Wagner A, Deluigi CC, et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation. 2006;114(15):1581-1590.

    Not in our library10.1161/circulationaha.105.606509

27. 27.

    Yamaguchi N, Takatsuka H, Wakae T, et al. Idiopathic interstitial pneumonia following stem cell transplantation. Clinical Transplantation. 2003;17(4):338-346.

    Not in our library10.1034/j.1399-0012.2003.00053.x

28. 28.

    Cone RW, Hackman RC, Huang ML, et al. Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. The New England Journal of Medicine. 1993;329(3):156-161.

    Not in our library10.1056/nejm199307153290302

29. 29.

    Hammerling JA, Lambrecht RS, Kehl KS, Carrigan DR. Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis. Journal of Clinical Pathology. 1996;49(10):802-804.

    Not in our library10.1136/jcp.49.10.802

30. 30.

    Kano Y, M Inaoka, Shiohara T. Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia. Archives of Dermatology. 2004;140(2):183-188.

    Not in our library10.1001/archderm.140.2.183

31. 31.

    Takatsuka H, Wakae T, Mori A, et al. Endothelial damage caused by cytomegalovirus and human herpesvirus-6. Bone Marrow Transplantation. 2003;31(6):475-479.

    Not in our library10.1038/sj.bmt.1703879

32. 32.

    Matsuda Y, Hara J, Miyoshi H, et al. Thrombotic microangiopathy associated with reactivation of human herpesvirus-6 following high-dose chemotherapy with autologous bone marrow transplantation in young children. Bone Marrow Transplantation. 1999;24(8):919-923.

    Not in our library10.1038/sj.bmt.1702003

33. 33.

    Martinez A, Alvarez-Lafuente R, Mas A, et al. Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA. Human Immunology. 2007;68(8):685-689.

    Not in our library10.1016/j.humimm.2007.05.005

34. 34.

    Garcia-Montojo M, De Las Heras V, Dominguez-Mozo M, et al. Human herpesvirus 6 and effectiveness of interferon beta 1b in multiple sclerosis patients. European Journal of Neurology. 2011;18(8):1027-1035.

    Not in our library10.1111/j.1468-1331.2011.03410.x

35. 35.

    Lusso P, Crowley RW, Malnati MS, et al. Human herpesvirus 6Aaccelerates AIDS progression in macaques. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(12):5067-5072.

    Not in our library10.1073/pnas.0700929104

36. 36.

    Lusso P, Gallo RC. Human herpesvirus 6 in AIDS. Immunology Today. 1995;16(2):67-71.

    Not in our library10.1016/0167-5699(95)80090-5

37. 37.

    Emery VC, Atkins MC, Bowen EF, et al. Interactions between beta-herpesviruses and human immunodeficiency virus in vivo: evidence for increased human immunodeficiency viral load in the presence of human herpesvirus 6. Journal of Medical Virology. 1999;57(3):278-282.

    Not in our library10.1002/(sici)1096-9071(199903)57:3<278::aid-jmv11>3.0.co;2-3

38. 38.

    Crawford JR, Kadom N, Santi MR, Mariani B, Lavenstein BL. Human herpesvirus 6 rhombencephalitis in immunocompetent children. Journal of Child Neurology. 2007;22(11):1260-1268.

    Not in our library10.1177/0883073807307086

39. 39.

    Potenza L, Luppi M, Barozzi P, et al. HHV-6A in syncytial giant-cell hepatitis. The New England Journal of Medicine. 2008;359(6):593-602.

    Not in our library10.1056/nejmoa074479

40. 40.

    Ablashi DV, Devin CL, Yoshikawa T, et al. Review part 3: human herpesvirus-6 in multiple non-neurological diseases. Journal of Medical Virology. 2010;82(11):1903-1910.

    Not in our library10.1002/jmv.21860

41. 41.

    Yao K, Crawford JR, Komaroff AL, Ablashi DV, Jacobson S. Review part 2: human herpesvirus-6 in central nervous system diseases. Journal of Medical Virology. 2010;82(10):1669-1678.

    Not in our library10.1002/jmv.21861

42. 42.

    Luppi M, Barozzi P, Bosco R, et al. Human herpesvirus 6 latency characterized by high viral load: chromosomal integration in many, but not all, cells. Journal of Infectious Diseases. 2006;194(7):1020-1021.

    Not in our library10.1086/506952

43. 43.

    Clark DA, Nacheva EP, Leong HN, et al. Transmission of integrated human herpesvirus 6 through stem cell transplantation: implications for laboratory diagnosis. Journal of Infectious Diseases. 2006;193(7):912-916.

    Not in our library10.1086/500838

44. 44.

    Kamble RT, Clark DA, Leong HN, Heslop HE, Brenner MK, Carrum G. Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation. 2007;40(6):563-566.

    Not in our library10.1038/sj.bmt.1705780

45. 45.

    Parcells MS, Arumugaswami V, Prigge JT, Pandya K, Dienglewicz RL. Marek's disease virus reactivation from latency: changes in gene expression at the origin of replication. Poultry Science. 2003;82(6):893-898.

    Not in our library10.1093/ps/82.6.893

46. 46.

    Reisinger J, Rumpler S, Lion T, Ambros PF. Visualization of episomal and integrated Epstein-Barr virus DNA by fiber fluorescence in situ hybridization. International Journal of Cancer. 2006;118(7):1603-1608.

    Not in our library10.1002/ijc.21498

47. 47.

    Hubacek P, Maalouf J, Zajickova M, et al. Failure of multiple antivirals to affect high HHV-6 DNAaemia resulting from viral chromosomal integration in case of severe aplastic anaemia. Haematologica. 2007;92(10):e98-e100.

    Not in our library10.3324/haematol.11592

48. 48.

    Arbuckle JH, Medveczky MM, Luka J, et al. The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(12):5563-5568.

    Not in our library10.1073/pnas.0913586107

49. 49.

    Delecluse HJ, W Hammerschmidt. Status of Marek's disease virus in established lymphoma cell lines: herpesvirus integration is common. Journal of Virology. 1993;67(1):82-92.

    Not in our library10.1128/jvi.67.1.82-92.1993

50. 50.

    Hall CB, Caserta MT, Schnabel KC, et al. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. Journal of Infectious Diseases. 2010;201(4):505-507.

    Not in our library10.1086/650495

51. 51.

    Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, et al. Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on human herpesvirus 6 replication in vitro. European Journal of Dermatology. 2010;20(1):68-73.

    Not in our library10.1684/ejd.2010.0821

52. 52.

    Mardivirin L, Descamps V, Lacroix A, Delebassee S, Ranger-Rogez S. Early effects of drugs responsible for DRESS on HHV-6 replication in vitro. Journal of Clinical Virology. 2009;46(3):300-302.

    Not in our library10.1016/j.jcv.2009.08.006

53. 53.

    Eshki M, Allanore L, Musette P, et al. Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure. Archives of Dermatology. 2009;145(1):67-72.

    Not in our library10.1001/archderm.145.1.67

54. 54.

    Caserta MT, Hall CB, Schnabel K, et al. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). Journal of Clinical Virology. 2010;48(1):55-57.

    Not in our library10.1016/j.jcv.2010.02.007

55. 55.

    Leong HN, Tuke PW, Tedder RS, et al. The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors. Journal of Medical Virology. 2007;79(1):45-51.

    Not in our library10.1002/jmv.20760

56. 56.

    Deback C, Geli J, Ait-Arkoub Z, et al. Use of the Roche LightCycler 480 system in a routine laboratory setting for molecular diagnosis of opportunistic viral infections: evaluation on whole blood specimens and proficiency panels. Journal of Virological Methods. 2009;159(2):291-294.

    Not in our library10.1016/j.jviromet.2009.03.027

57. 57.

    Ward KN, Leong HN, Nacheva EP, et al. Human herpesvirus 6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. Journal of Clinical Microbiology. 2006;44(4):1571-1574.

    Not in our library10.1128/jcm.44.4.1571-1574.2006

58. 58.

    Hall CB, Caserta MT, Schnabel K, et al. Chromosomal integration of human herpesvirus 6 is the major mode of congenital human herpesvirus 6 infection. Pediatrics. 2008;122(3):513-520.

    Not in our library10.1542/peds.2007-2838

59. 59.

    Ogata M, Kikuchi H, Satou T, et al. Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance. Journal of Infectious Diseases. 2006;193(1):68-79.

    Not in our library10.1086/498531

60. 60.

    Secchiero P, Carrigan DR, Asano Y, et al. Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction. Journal of Infectious Diseases. 1995;171(2):273-280.

    Not in our library10.1093/infdis/171.2.273

61. 61.

    Brands-Nijenhuis AV, van Loo IH, Schouten HC, van Gelder M. Temporal relationship between HHV 6 and graft vs host disease in a patient after haplo-identical SCT and severe T-cell depletion. Bone Marrow Transplant. 2010.

    Not in our library10.1038/bmt.2010.245

62. 62.

    Gautheret-Dejean A, Henquell C, Mousnier F, et al. Different expression of human herpesvirus-6 (HHV-6) load in whole blood may have a significant impact on the diagnosis of active infection. Journal of Clinical Virology. 2009;46(1):33-36.

    Not in our library10.1016/j.jcv.2009.05.020

63. 63.

    Ward KN, Leong HN, Thiruchelvam AD, Atkinson CE, Clark DA. Human herpesvirus 6 DNA levels in cerebrospinal fluid due to primary infection differ from those due to chromosomal viral integration and have implications for diagnosis of encephalitis. Journal of Clinical Microbiology. 2007;45(4):1298-1304.

    Not in our library10.1128/jcm.02115-06

64. 64.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

65. 65.

    Hubacek P, Virgili A, Ward KN, et al. HHV-6 DNA throughout the tissues of two stem cell transplant patients with chromosomally integrated HHV-6 and fatal CMV pneumonitis. British Journal of Haematology. 2009;145(3):394-398.

    Not in our library10.1111/j.1365-2141.2009.07622.x

66. 66.

    Tanaka-Taya K, Sashihara J, Kurahashi H, et al. Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. Journal of Medical Virology. 2004;73(3):465-473.

    Not in our library10.1002/jmv.20113

67. 67.

    Loginov R, Karlsson T, Hockerstedt K, Ablashi D, Lautenschlager I. Quantitative HHV-6B antigenemia test for the monitoring of transplant patients. European Journal of Clinical Microbiology and Infectious Diseases. 2010;29(7):881-886.

    Not in our library10.1007/s10096-010-0923-1

68. 68.

    Flamand L, Komaroff AL, Arbuckle JH, Medveczky PG, Ablashi DV. Review, part 1: human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy. Journal of Medical Virology. 2010;82(9):1560-1568.

    Not in our library10.1002/jmv.21839

69. 69.

    Ishiyama K, Katagiri T, Ohata K, et al. Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation. Transpl Infect Dis. 2011.

    Not in our library10.1111/j.1399-3062.2011.00662.x

70. 70.

    Tokimasa S, Hara J, Osugi Y, et al. Ganciclovir is effective for prophylaxis and treatment of human herpesvirus-6 in allogeneic stem cell transplantation. Bone Marrow Transplantation. 2002;29(7):595-598.

    Not in our library10.1038/sj.bmt.1703423

71. 71.

    Rapaport D, Engelhard D, Tagger G, Or R, Frenkel N. Antiviral prophylaxis may prevent human herpesvirus-6 reactivation in bone marrow transplant recipients. Transplant Infectious Disease. 2002;4(1):10-16.

    Not in our library10.1034/j.1399-3062.2002.040101.x

72. 72.

    Razonable RR, Zerr DM. HHV-6, HHV-7 and HHV-8 in solid organ transplant recipients. American Journal of Transplantation. 2009;9(Suppl 4):S97-S100.

    Not in our library10.1111/j.1600-6143.2009.02899_1.x

73. 73.

    Zerr DM, Gupta D, Huang ML, Carter R, Corey L. Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clinical Infectious Diseases. 2002;34(3):309-317.

    Not in our library10.1086/338044

74. 74.

    Lautenschlager I, Lappalainen M, Linnavuori K, Suni J, Hockerstedt K. CMV infection is usually associated with concurrent HHV-6 and HHV-7 antigenemia in liver transplant patients. Journal of Clinical Virology. 2002;25(Suppl 2):S57-S61.

    Not in our library10.1016/s1386-6532(02)00101-4

75. 75.

    Ishiyama K, Katagiri T, Hoshino T, Yoshida T, Yamaguchi M, Nakao S. Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT. Bone Marrow Transplant. 2010.

    Not in our library10.1038/bmt.2010.201

76. 76.

    Ljungman P, de la Camara R, Cordonnier C, et al. Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplantation. 2008;42(4):227-240.

    Not in our library10.1038/bmt.2008.162

77. 77.

    Hall CB, Caserta MT, Schnabel KC, et al. Congenital infections with human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7). Journal de Pediatria. 2004;145(4):472-477.

    Not in our library10.1016/j.jpeds.2004.06.017

78. 78.

    Hudnall SD, Chen T, Allison P, Tyring SK, Heath A. Herpesvirus prevalence and viral load in healthy blood donors by quantitative real-time polymerase chain reaction. Transfusion. 2008;48(6):1180-1187.

    Not in our library10.1111/j.1537-2995.2008.01685.x

79. 79.

    Ward KN, Thiruchelvam AD, Couto-Parada X. Unexpected occasional persistence of high levels of HHV-6 DNA in sera: detection of variants A and B. Journal of Medical Virology. 2005;76(4):563-570.

    Not in our library10.1002/jmv.20399

80. 80.

    Lee SO, Brown RA, Razonable RRl. Clinical Significance of Pretransplant Chromosomally Integrated Human Herpesvirus-6 in Liver Transplant Recipients. Transplantation. 2011.

    Not in our library10.1097/tp.0b013e318222444a

81. 81.

    Griffiths PD, Ait-Khaled M, Bearcroft CP, et al. Human herpesviruses 6 and 7 as potential pathogens after liver transplant: prospective comparison with the effect of cytomegalovirus. Journal of Medical Virology. 1999;59(4):496-501.

    Not in our library10.1002/(sici)1096-9071(199912)59:4<496::aid-jmv12>3.0.co;2-u

82. 82.

    Hubacek P, Muzikova K, Hrdlickova A, et al. Prevalence of HHV-6 integrated chromosomally among children treated for acute lymphoblastic or myeloid leukemia in the Czech Republic. Journal of Medical Virology. 2009;81(2):258-263.

    Not in our library10.1002/jmv.21371

83. 83.

    Potenza L, Barozzi P, Masetti M, et al. Prevalence of human herpesvirus-6 chromosomal integration (CIHHV-6) in Italian solid organ and allogeneic stem cell transplant patients. American Journal of Transplantation. 2009;9(7):1690-1697.

    Not in our library10.1111/j.1600-6143.2009.02685.x

84. 84.

    Ward KN. The natural history and laboratory diagnosis of human herpesviruses-6 and −7 infections in the immunocompetent. Journal of Clinical Virology. 2005;32(3):183-193.

    Not in our library10.1016/j.jcv.2004.11.008

85. 85.

    Torelli G, Barozzi P, Marasca R, et al. Targeted integration of human herpesvirus 6 in the p arm of chromosome 17 of human peripheral blood mononuclear cells in vivo. Journal of Medical Virology. 1995;46(3):178-188.

    Not in our library10.1002/jmv.1890460303

86. 86.

    Kidd IM, Clark DA, Sabin CA, et al. Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection. Transplantation. 2000;69(11):2400-2404.

    Not in our library10.1097/00007890-200006150-00032

87. 87.

    Lee SO, Brown RA, Eid AJ, Razonable RR. Chromosomally integrated human herpesvirus-6 in kidney transplant recipients. Nephrology, Dialysis, Transplantation. 2011;26(7):2391-2393.

    Not in our library10.1093/ndt/gfr259

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