Evolution and functional cross‐talk of protein post‐translational modifications

Abstract

Protein post-translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTMs and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTMs that were spurred by these technological improvements. We provide an overview of studies focusing on the origin and evolution of regulatory enzymes as well as the evolutionary dynamics of modification sites. Finally, we discuss different mechanisms of altering protein activity via post-translational regulation and progress made in the large-scale functional characterization of PTM function.

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     Not in our library10.1016/j.ydbio.2010.10.013

107. 107.

     Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C (2013 ) Acetyl‐phosphate is a critical determinant of lysine acetylation in E. coli. Mol Cell51: 265–272

     Not in our library10.1016/j.molcel.2013.06.003

108. 108.

     Woodsmith J, Kamburov A, Stelzl U (2013 ) Dual coordination of post translational modifications in human protein networks. PLoS Comput Biol9: e1002933

     Not in our library10.1371/journal.pcbi.1002933

109. 109.

     Wu R, Haas W, Dephoure N, Huttlin EL, Zhai B, Sowa ME, Gygi SP (2011 ) A large‐scale method to measure absolute protein phosphorylation stoichiometries. Nat Methods8: 677–683

     Not in our library10.1038/nmeth.1636

110. 110.

     Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y (2013 ) Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics. J Proteomics79: 60–71

     Not in our library10.1016/j.jprot.2012.12.001

111. 111.

     Xin X, Gfeller D, Cheng J, Tonikian R, Sun L, Guo A, Lopez L, Pavlenco A, Akintobi A, Zhang Y, Rual J‐F, Currell B, Seshagiri S, Hao T, Yang X, Shen YA, Salehi‐Ashtiani K, Li J, Cheng AT, Bouamalay D et al (2013 ) SH3 interactome conserves general function over specific form. Mol Syst Biol9: 1–17

     Not in our library10.1038/msb.2013.9

112. 112.

     Zanzoni A, Carbajo D, Diella F, Gherardini PF, Tramontano A, Helmer‐Citterich M, Via A (2011 ) Phospho3D 2.0: an enhanced database of three‐dimensional structures of phosphorylation sites. Nucleic Acids Res39: D268–D271

     Not in our library10.1093/nar/gkq936

113. 113.
     Essential Functions of Protein Tyrosine Phosphatases Ptp2 and Ptp3 and Rim11 Tyrosine Phosphorylation in Saccharomyces cerevisiae Meiosis and Sporulation · 2000

     Not checked
114. 114.

     Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu C‐F, Grishin NV, Zhao Y (2009 ) Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics8: 215–225

     Not in our library10.1074/mcp.m800187-mcp200

115. 115.

     Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z (2013 ) Comprehensive profiling of protein lysine acetylation in Escherichia coli. J Proteome Res12: 844–851

     Not in our library10.1021/pr300912q

116. 116.

     Zielinska DF, Gnad F, Schropp K, Wiśniewski JR, Mann M (2012 ) Mapping N‐glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery. Mol Cell46: 542–548

     Not in our library10.1016/j.molcel.2012.04.031

117. 117.

     Zlocowski N, Sendra VG, Lorenz V, Villarreal MA, Jorge A, Núñez Y, Bennett EP, Clausen H, Nores GA, Irazoqui FJ (2011 ) Catalytic and glycan‐binding abilities of ppGalNAc‐T2 are regulated by acetylation. Biochem Biophys Res Commun410: 140–145

     Not in our library10.1016/j.bbrc.2011.05.125

Cited by papers we hold 8

• Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications · 2023
  No notice
• Protein post-translational modifications: In silico prediction tools and molecular modeling · 2017
  No notice
• The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97 · 2017
  No notice
• Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases · 2016
  No notice
• Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling · 2015
  No notice
• The Roles of Post-translational Modifications in the Context of Protein Interaction Networks · 2015
  No notice
• Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity · 2014
  Not checked
• Physicochemical mechanisms of protein regulation by phosphorylation · 2014
  No notice

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