No retraction, correction or concern found when last checked on Oct 21, 2026.

Metabolite profiling of human‐originated Lachnospiraceae at the strain level

Rashidin Abdugheni, Wen‐Zhao Wang, Yu‐Jing Wang and 9 more

iMeta · 2022 · CC BY

Abstract

The human gastrointestinal (GI) tract harbors diverse microbes, and the family Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the human GI tract. Beneficial and adverse effects of the Lachnospiraceae on host health were reported, but the diversities at species/strain levels as well as their metabolites of Lachnospiraceae have been, so far, not well documented. In the present study, we report on the collection of 77 h uman‐originated L a ch nospiraceae sp ecies (please refer hLchsp, https://hgmb.nmdc.cn/subject/lachnospiraceae ) and the in vitro metabolite profiles of 110 Lachnospiraceae strains ( https://hgmb.nmdc.cn/subject/lachnospiraceae/metabolites ). The Lachnospiraceae strains in hLchsp produced 242 metabolites of 17 categories. The larger categories were alcohols (89), ketones (35), pyrazines (29), short (C2–C5), and long (C > 5) chain acids (31), phenols (14), aldehydes (14), and other 30 compounds. Among them, 22 metabolites were aromatic compounds. The well‐known beneficial gut microbial metabolite, butyric acid, was generally produced by many Lachnospiraceae strains, and Agathobacter rectalis strain Lach‐101 and Coprococcus comes strain NSJ‐173 were the top 2 butyric acid producers, as 331.5 and 310.9 mg/L of butyric acids were produced in vitro, respectively. Further analysis of the publicly available cohort‐based volatile‐metabolomic data sets of human feces revealed that over 30% of the prevailing volatile metabolites were covered by Lachnospiraceae metabolites identified in this study. This study provides Lachnospiraceae strain resources together with their metabolic profiles for future studies on host–microbe interactions and developments of novel probiotics or biotherapies.

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88.
Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation · 2016
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89.
Culture of previously uncultured members of the human gut microbiota by culturomics · 2016
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90.
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96.
Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity · 2017
No notice
97.
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98.
Mutual interaction between gut microbiota and protein/amino acid metabolism for host mucosal immunity and health · 2021
Not checked
99.
Blautia genus associated with visceral fat accumulation in adults 20–76 years of age · 2019
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100.
Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening · 2020
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Automated analysis of genomic sequences facilitates high-throughput and comprehensive description of bacteria · 2021
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104.
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105.
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106.
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107.
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112.
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Microbial tryptophan catabolites in health and disease · 2018
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Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health · 2019
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