Medial temporal lobe activation during encoding and retrieval of novel face‐name pairs

Abstract

The human medial temporal lobe (MTL) is known to be involved in declarative memory, yet the exact contributions of the various MTL structures are not well understood. In particular, the data as to whether the hippocampal region is preferentially involved in the encoding and/or retrieval of associative memory have not allowed for a consensus concerning its specific role. To investigate the role of the hippocampal region and the nearby MTL cortical areas in encoding and retrieval of associative versus non‐associative memories, we used functional magnetic resonance imaging (fMRI) to measure brain activity during learning and later recognition testing of novel face‐name pairs. We show that there is greater activity for successful encoding of associative information than for non‐associative information in the right hippocampal region, as well as in the left amygdala and right parahippocampal cortex. Activity for retrieval of associative information was greater than for non‐associative information in the right hippocampal region also, as well as in the left perirhinal cortex, right entorhinal cortex, and right parahippocampal cortex. The implications of these data for a clear functional distinction between the hippocampal region and the MTL cortical structures are discussed. © 2004 Wiley‐Liss, Inc.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 65

1. 1.

   Aggleton JP, Brown MW. Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behav Brain Sci. 1999;22:425-489.

   Not in our library

2. 2.

   Brewer JB, Zhao Z, Desmond JE, Glover GH, Gabrieli JD. Making memories: brain activity that predicts how well visual experience will be remembered. Science. 1998;281:1185-1187.

   Not in our library10.1126/science.281.5380.1185

3. 3.

   Broadbent NJ, Clark RE, Zola SM, Squire LR, Squire LR, Schacter DL. The medial temporal lobe and memory. The neuropsychology of memory. 2002;3-23.

   Not in our library

4. 4.

   Brown MW, Aggleton JP. Recognition memory: what are the roles of the perirhinal cortex and hippocampus? Nat Rev Neurosci. 2001;2:51-61.

   Not in our library10.1038/35049064

5. 5.

   Buckley MJ, Gaffan D. Perirhinal cortex ablation impairs configural learning and paired-associate learning equally. Neuropsychologia. 1998;36:535-546.

   Not in our library10.1016/s0028-3932(97)00120-6

6. 6.

   Cameron KA, Yashar S, Wilson C, Fried I. Human hippocampal neurons predict how well word pairs will be remembered. Neuron. 2001;30:289-298.

   Not in our library10.1016/s0896-6273(01)00280-x

7. 7.

   Cohen NJ, Eichenbaum H. Memory, amnesia, and the hippocampal system. 1993.

   Not in our library

8. 8.

   Cohen NJ, Poldrack RA, Eichenbaum H. Memory for items and memory for relations in the procedural/declarative memory framework. Memory. 1997;5:131-178.

   Not in our library10.1080/741941149

9. 9.

   Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996;29:162-163.

   Not in our library10.1006/cbmr.1996.0014

10. 10.

    Davachi L, Wagner AD. Hippocampal contributions to episodic encoding: insights from relational and item-based learning. J Neurophysiol. 2002;88:982-990.

    Not in our library10.1152/jn.2002.88.2.982

11. 11.

    Davachi L, Mitchell J, Wagner AD. Multiple routes to memory: distinct medial temporal lobe processes build up item and source memories. Proc Natl Acad Sci USA. 2003;100:2157-2162.

    Not in our library10.1073/pnas.0337195100

12. 12.

    Dobbins IG, Rice HJ, Wagner AD, Schacter DL. Memory orientation and success: separable neurocognitive components underlying episodic recognition. Neuropsychologia. 2002;41:318-333.

    Not in our library10.1016/s0028-3932(02)00164-1

13. 13.

    Düzel E, Habib R, Rotte M, Guderian S, Tulving E, Heinze H-J. Human hippocampal and parahippocampal activity during visual associative recognition memory for spatial and nonspatial stimulus configurations. J Neurosci. 2003;23:9439-9444.

    Not in our library10.1523/jneurosci.23-28-09439.2003

14. 14.

    Eichenbaum H. A cortical-hippocampal system for declarative memory. Nat Rev Neurosci. 2000;1:41-50.

    Not in our library10.1038/35036213

15. 15.

    Eichenbaum H, Otto T, Cohen NJ. Two component functions of the hippocampal memory system. Behav Brain Sci. 1994;17:449-517.

    Not in our library

16. 16.

    Eichenbaum H, Schoenbaum G, Young B, Bunsey M. Functional organization of the hippocampal memory system. Proc Natl Acad Sci USA. 1996;93:13500-13507.

    Not in our library10.1073/pnas.93.24.13500

17. 17.

    Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA. Remembering episodes: a selective role for the hippocampus during retrieval. Nat Neurosci. 2000;3:1149-1152.

    Not in our library10.1038/80671

18. 18.

    Fernandez G, Effern A, Grunwald T, Pezer N, Lehnertz K, Dumpelmann M, Van Roost D, Elger CE. Real-time tracking of memory formation in the human rhinal cortex and hippocampus. Science. 1999;285:1582-1585.

    Not in our library10.1126/science.285.5433.1582

19. 19.

    Fernandez G, Klaver P, Fell J, Grunwald T, Elger CE. Human declarative memory formation: segregating rhinal and hippocampal contributions. Hippocampus. 2002;12:514-519.

    Not in our library10.1002/hipo.10050

20. 20.

    Fried I, MacDonald K, Wilson C. Single neuron activity in human hippocampus and amygdala during recognition of faces and objects. Neuron. 1997;18:753-765.

    Not in our library10.1016/s0896-6273(00)80315-3

21. 21.

    Henke K, Buck A, Weber B, Wieser HG. Human hippocampus establishes associations in memory. Hippocampus. 1997;7:249-256.

    Not in our library10.1002/(sici)1098-1063(1997)7:3<249::aid-hipo1>3.0.co;2-g

22. 22.

    Henke K, Weber B, Kneifel S, Wieser HG, Buck A. Human hippocampus associates information in memory. Proc Natl Acad Sci USA. 1999;96:5884-5889.

    Not in our library10.1073/pnas.96.10.5884

23. 23.

    Henson RNA, Rugg MD, Shallice T, Josephs O, Dolan RJ. Recollection and familiarity in recognition memory: an event-related functional magnetic resonance imaging study. J Neurosci. 1999;19:3962-3972.

    Not in our library10.1523/jneurosci.19-10-03962.1999

24. 24.

    Henson RNA, Cansino S, Herron J, Robb W, Rugg MD. A familiarity signal in human anterior medial temporal cortex? Hippocampus. 2003;13:301-304.

    Not in our library10.1002/hipo.10117

25. 25.

    Hicks JL, Marsh RL. Remember-know judgments can depend on how memory is tested. Psychon Bull Rev. 1999;6:117-122.

    Not in our library10.3758/bf03210818

26. 26.

    Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, Laakso MP, Pitkanen A. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR Am J Neuroradiol. 1998;19:659-671.

    Not in our library

27. 27.

    Jackson O, Schacter DL. Encoding activity in anterior medial temporal lobe supports subsequent associative recognition. Neuroimage. 2004;21:456-462.

    Not in our library10.1016/j.neuroimage.2003.09.050

28. 28.

    Killgore WDS, Casasanto DJ, Yurgelun-Todd DA, Maldjian JA, Detre JA. Functional activation of the left amygdala and hippocampus during associative encoding. NeuroReport. 2000;11:2259-2263.

    Not in our library10.1097/00001756-200007140-00039

29. 29.

    Lavenex P, Amaral DG. Hippocampal-neocortical interaction: a hierarchy of associativity. Hippocampus. 2000;10:420-430.

    Not in our library10.1002/1098-1063(2000)10:4<420::aid-hipo8>3.0.co;2-5

30. 30.

    Mayes AR, Holdstock JS, Isaac CL, Hunkin NM, Roberts N. Relative sparing of item recognition memory in a patient with adult-onset damage limited to the hippocampus. Hippocampus. 2002;12:325-340.

    Not in our library10.1002/hipo.1111

31. 31.

    Milner B, Squire LR, Kandel ER. Cognitive neuroscience and the study of memory. Neuron. 1998;20:445-468.

    Not in our library10.1016/s0896-6273(00)80987-3

32. 32.

    Norman KA, O'Reilly RC. Modeling hippocampal and neocortical contributions to recognition memory: a complementary learning systems approach. Psychological Review. 2003;110:611-646.

    Not in our library10.1037/0033-295x.110.4.611

33. 33.

    O'Reilly RC, Rudy JW. Computational principles of learning in the neocortex and hippocampus. Hippocampus. 2000;10:389-397.

    Not in our library10.1002/1098-1063(2000)10:4<389::aid-hipo5>3.0.co;2-p

34. 34.

    Otten LJ, Henson RNA, Rugg MD. Depth of processing effects on neural correlates of memory encoding: relationship between findings across- and within-task comparisons. Brain. 2001;124:399-412.

    Not in our library10.1093/brain/124.2.399

35. 35.

    Pihlajamaki M, Tanila H, Hanninen T, Kononen M, Mikkonen M, Jalkanen V, Partanen K, Soininen H. Encoding of novel picture pairs activates the perirhinal cortex: an fMRI study. Hippocampus. 2003;13:67-80.

    Not in our library10.1002/hipo.10049

36. 36.

    Preuessner J, Kohler S, Crane J, Pruessner M, Lord C, Byrne A, Kabani N, Collins DL, Evans AC. Volumetry of temporopolar, perirhinal, entorhinal, and parahippocampal cortex from high-resolution MR images: considering the variability of the collateral sulcus. Cereb Cortex. 2002;12:1342-1353.

    Not in our library10.1093/cercor/12.12.1342

37. 37.

    Pruessmann K, Weiger M, Scheidegger N, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med. 1999;42:952-962.

    Not in our library

38. 38.

    Ranganath C, Yonelinas AP, Cohen MX, Dy CJ, Tom SM, D'Esposito MD. Dissociable correlates of recollection and familiarity within the medial temporal lobes. Neuropsychologia. 2004;42:2-13.

    Not in our library10.1016/j.neuropsychologia.2003.07.006

39. 39.

    Reed JM, Squire LR. Impaired transverse patterning in human amnesia is a special case of impaired memory for two-choice discrimination tasks. Behav Neurosci. 1999;113:3-9.

    Not in our library10.1037//0735-7044.113.1.3

40. 40.

    Rolls ET, Treves A. Neural networks and brain function. 1998.

    Not in our library

Cited by papers we hold 3

• Microstructural Alterations in Hippocampal Subfields Mediate Age-Related Memory Decline in Humans · 2020
  Not checked
• Learning-related representational changes reveal dissociable integration and separation signatures in the hippocampus and prefrontal cortex · 2015
  No notice
• Rapid Encoding of New Memories by Individual Neurons in the Human Brain · 2015
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.