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The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak
Helge Karch, Erick Denamur, Ulrich Dobrindt and 7 more
EMBO Molecular Medicine · 2012 · Review · CC BY-NC
Abstract
In response to the 2011 European health alert caused by a pathogenic Escherichia coli O104:H4 outbreak, the European Academy of Microbiology (EAM), established by the Federation of European Microbiological Societies (FEMS), convened a meeting in Paris on November 30th, 2011 on 'EHEC infection and control' attended by world renowned experts in pathogenic E. coli. The major aims of this group were to review the scientific issues raised by the outbreak, to assess the handling of the crisis at the scientific and political levels, and to propose future actions. Several conclusions, which will have impact on future potential E. coli outbreaks, are outlined here.
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References 35
- 1.
Allen KJ, Rogan D, Finlay BB, Potter AA, Asper DJ. Vaccination with type III secreted proteins leads to decreased shedding in calves after experimental infection with Escherichia coli O157. Can J Vet Res. 2011;75:98-105.
Not in our library
- 2.
Auvray F, Dilasser F, Bibbal D, Kérourédan M, Oswald E, Brugère H. French cattle is not a reservoir of the highly virulent enteroaggregative Shiga toxin-producing Escherichia coli of serotype O104:H4. Vet Microbiol. 2012;158:443-445.
Not in our library10.1016/j.vetmic.2012.02.029
- 3.
Bielaszewska M, Idelevich EA, Zhang W, Bauwens A, Schaumburg F, Mellmann A, Peters G, Karch H. Effects of antibiotics on Shiga toxin 2 production and bacteriophage induction by epidemic Escherichia coli O104:H4 strain. Antimicrob Agents Chemother. 2012;56:3277-3282.
Not in our library10.1128/aac.06315-11
- 4.
Bielaszewska M, Mellmann A, Zhang W, Köck R, Fruth A, Bauwens A, Peters G, Karch H. Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect Dis. 2011;11:671-676.
Not in our library10.1016/s1473-3099(11)70165-7
- 5.
Brzuszkiewicz E, Thürmer A, Schuldes J, Leimbach A, Liesegang H, Boelter J, Petersen H, Gottschalk G, Daniel R. Genome sequence analyses of two isolates from the recent Escherichia coli outbreak in Germany reveal the emergence of a new pathotype: Entero-Aggregative-Haemorrhagic Escherichia coli (EAHEC). Arch Microbiol. 2011;193:883-891.
Not in our library10.1007/s00203-011-0725-6
- 6.
Buchholz U, Bernard H, Werber D, Böhmer MM, Remschmidt C, Wilking H, Deleré Y, an der Heiden M, Adlhoch C, Dreesman M, et al. German outbreak of Escherichia coli O104:H4 associated with sprouts. N Engl J Med. 2011;365:1763-1770.
Not in our library10.1056/nejmoa1106482
- 7.
Chatelet V, Fremeaux-Bacchi V, Lobbedez T, Ficheux M, Hurault de Ligny B. Safety and long-term efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome. Am J Transplant. 2009;9:2644-2645.
Not in our library10.1111/j.1600-6143.2009.02817.x
- 8.
Croxen MA, Finlay BB. Molecular mechanisms of Escherichia coli pathogenicity. Nat Rev Microbiol. 2010;8:26-38.
Not in our library10.1038/nrmicro2265
- 9.
Denamur E. The (2011) Shiga toxin-producing Escherichia coli O104:H4 German outbreak: a lesson in genomic plasticity. Clin Microbiol Infect. 2011;17:1124-1125.
Not in our library10.1111/j.1469-0691.2011.03620.x
- 10.
Donnenberg MS, Tzipori S, McKee ML, O'Brien AD, Alroy J, Kaper JB. The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model. J Clin Invest. 1993;92:1418-1424.
Not in our library10.1172/jci116718
- 11.
2011.
Not in our library
- 12.
Ewers H, Römer W, Smith AE, Bacia K, Dmitrieff S, Chai W, Mancini R, Kartenbeck J, Chambon V, Berland L, et al. GM1 structure determines SV40-induced membrane invagination and infection. Nat Cell Biol. 2010;12:11-18.
Not in our library10.1038/ncb1999
- 13.
Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, Bernard H, Fruth A, Prager R, Spode A, et al. Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med. 2011;365:1771-1780.
Not in our library10.1056/nejmoa1106483
- 14.
Grad YH, Lipsitch M, Feldgarden M, Arachchi HM, Cerqueira GC, Fitzgerald M, Godfrey P, Haas BJ, Murphy CI, Russ C, et al. Genomic epidemiology of the Escherichia coli O104:H4 outbreaks in Europe, 2011. Proc Nat Acad Sci. 2012;109:3065-3070.
Not in our library10.1073/pnas.1121491109
- 15.
Greinacher A, Friesecke S, Abel P, Dressel A, Stracke S, Fiene M, Ernst F, Selleng K, Weissenborn K, Schmidt BM, et al. Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial. Lancet. 2011;378:1166-1173.
Not in our library10.1016/s0140-6736(11)61253-1
- 16.
Harrington SM, Dudley EG, Nataro JP. Pathogenesis of enteroaggregative Escherichia coli infection. FEMS Microbiol Lett. 2006;254:12-18.
Not in our library10.1111/j.1574-6968.2005.00005.x
- 17.
Jansen A, Kielstein JT. The new face of enterohaemorrhagic Escherichia coli infections. Euro Surveill. 2011;16.
Not in our library
- 18.
Kimmitt PT, Harwood CR, Barer MR. Toxin gene expression by Shiga toxin-producing Escherichia coli: the role of antibiotics and the bacterial SOS response. Emerg Infect Dis. 2000;6:458-465.
Not in our library10.3201/eid0605.000503
- 19.
Lapeyraque AL, Malina M, Fremeaux-Bacchi V, Boppel T, Kirschfink M, Oualha M, Proulx F, Clermont MJ, Le Deist F, Niaudet P, et al. Eculizumab in severe Shiga-toxin-associated HUS. N Engl J Med. 2011;364:2561-2563.
Not in our library10.1056/nejmc1100859
- 20.
- 21.
- 22.
Mora A, Herrera A, López C, Dahbi G, Mamani R, Pita JM, Alonso MP, Llovo J, Bernárdez MI, Blanco JE, et al. Characteristics of the Shiga-toxin-producing enteroaggregative Escherichia coli O104:H4 German outbreak strain and of STEC strains isolated in Spain. Internat Microbiol. 2011;14:121-141.
Not in our library10.2436/20.1501.01.142
- 23.
Mukhopadhyay S, Linstedt AD. Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis. Science. 2012;335:332-335.
Not in our library10.1126/science.1215930
- 24.
Okeke IN, Wallace-Gadsden F, Simons HR, Matthews N, Labar AS, Hwang J, Wain J. Multi-locus sequence typing of enteroaggregative Escherichia coli isolates from Nigerian children uncovers multiple lineages. PLoS ONE. 2010;5:e14093.
Not in our library10.1371/journal.pone.0014093
- 25.
Poirel L, Gniadkowski M, Nordmann P. Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum beta-lactamase CTX-M-15 and of its structurally related β-lactamase CTX-M-3. J Antimicrob Chemother. 2002;50:1031-1034.
Not in our library10.1093/jac/dkf240
- 26.
Rasko DA, Webster DR, Sahl JW, Bashir A, Boisen N, Scheutz F, Paxinos EE, Sebra R, Chin CS, Iliopoulos D, et al. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med. 2011;365:709-717.
Not in our library10.1056/nejmoa1106920
- 27.
Rohde H, Qin J, Cui Y, Li D, Loman NJ, Hentschke M, Chen W, Pu F, Peng Y, Li J, et al. E. coli O104:H4 genome analysis crowd-sourcing consortium. Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. N Engl J Med. 2011;365:718-724.
Not in our library10.1056/nejmoa1107643
- 28.
Römer W, Berland L, Chambon V, Gaus K, Windschiegl B, Tenza D, Aly MRE, Fraisier V, Florent JC, Perrais D, et al. Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature. 2007;450:670-675.
Not in our library10.1038/nature05996
- 29.
Seaman MNJ, Peden AA. Ricin toxin hits a retrograde roadblock. Cell. 2010;141:222-224.
Not in our library10.1016/j.cell.2010.03.044
- 30.
Stechmann B, Bai SK, Gobbo E, Lopez R, Merer G, Pinchard S, Panigai L, Tenza D, Raposo G, Beaumelle B, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010;141:231-242.
Not in our library10.1016/j.cell.2010.01.043
- 31.
Storz G, Hengge R. Bacterial Stress Responses. 2011.
Not in our library
- 32.
Tarr PI, Gordon CA, Chandler WL. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet. 2005;365:1073-1086.
Not in our library10.1016/s0140-6736(05)71144-2
- 33.
- 34.
- 35.
Wong CS, Mooney JC, Brandt JR, Staples AO, Jelacic S, Boster DR, Watkins SL, Tarr PI. Risk factors for the hemolytic uremic syndrome in children infected with Escherichia coli O157:H7: a multivariable analysis. Clin Infect Dis. 2012;55:33-41.
Not in our library10.1093/cid/cis299
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- Comparative Genomics and Characterization of the Late Promoter <i>p</i>R’ from Shiga Toxin Prophages in <i>Escherichia coli</i> · 2018Not checked
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