The role of Syk/CARD9 coupled C‐type lectins in antifungal immunity

Abstract

Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic infection has resulted in an unacceptably high mortality rate. It is therefore of importance that we understand immune mechanisms operating during fungal infections, in order to facilitate development of adjunctive immunotherapies for the treatment of these diseases. C‐type lectin receptors (CLRs) are pattern recognition receptors (PRRs) that are critical for immune responses to fungi. Many of these receptors are coupled to Syk kinase, which allows these receptors to signal via CARD9 leading to NF‐κB activation, which in turn contributes to the induction of both innate and adaptive immunity. Dectin‐1, Dectin‐2 and Mincle are all CLRs that share this common signalling mechanism and have been shown to play key roles in antifungal immunity. This review aims to update existing paradigms and summarise the most recent findings on these CLRs, their signal transduction mechanisms and the collaborations between these CLRs and other PRRs.

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References 49

1. 1.

   Saijo S, Fujikado N, Furuta T, Chung SH, Kotaki H, Seki K, Sudo K, et al. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat. Immunol. 2007;8:39-46.

   Not in our library10.1038/ni1425

2. 2.

   Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 2007;8:31-38.

   Not in our library10.1038/ni1408

3. 3.

   Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, et al. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 2010;32:681-691.

   Not in our library10.1016/j.immuni.2010.05.001

4. 4.

   Graham LM, Brown GD. The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine. 2009;48:148-155.

   Not in our library10.1016/j.cyto.2009.07.010

5. 5.

   Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M, et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 2007;8:619-629.

   Not in our library10.1038/ni1466

6. 6.

   Taylor PR, Tsoni SV, Willment JA, Dennehy KM, Rosas M, Findon H, Haynes K, et al. Dectin-1 is required for [beta]-glucan recognition and control of fungal infection. Nat. Immunol. 2007;8:31-38.

   Not in our library10.1038/ni1408

7. 7.

   Werner JL, Metz AE, Horn D, Schoeb TR, Hewitt MM, Schwiebert LM, Faro-Trindade I, et al. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 2009;182:4938-4946.

   Not in our library10.4049/jimmunol.0804250

8. 8.

   Saijo S, Fujikado N, Furuta T, Chung S-h, Kotaki H, Seki K, Sudo K, et al. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat. Immunol. 2007;8:39-46.

   Not in our library10.1038/ni1425

9. 9.

   Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, Elbers CC, et al. Human Dectin-1 deficiency and mucocutaneous fungal infections. N. Engl. J. Med. 2009;361:1760-1767.

   Not in our library10.1056/nejmoa0901053

10. 10.

    Heinsbroek SEM, Taylor PR, Rosas M, Willment JA, Williams DL, Gordon S, Brown GD. Expression of functionally different dectin-1 isoforms by murine macrophages. J. Immunol. 2006;176:5513-5518.

    Not in our library10.4049/jimmunol.176.9.5513

11. 11.

    Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 2006;6:33-43.

    Not in our library10.1038/nri1745

12. 12.

    Kumar H, Kumagai Y, Tsuchida T, Koenig PA, Satoh T, Guo Z, Jang MH, et al. Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan. J. Immunol. 2009;183:8061-8067.

    Not in our library10.4049/jimmunol.0902477

13. 13.

    LeibundGut-Landmann S, Osorio F, Brown GD, Sousa CRE. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood. 2008;112:4971-4980.

    Not in our library10.1182/blood-2008-05-158469

14. 14.

    Ni L, Gayet I, Zurawski S, Duluc D, Flamar AL, Li XH, O'Bar A, et al. Concomitant activation and antigen uptake via human Dectin-1 results in potent antigen-specific CD8(+) T cell responses. J. Immunol. 2010;185:3504-3513.

    Not in our library10.4049/jimmunol.1000999

15. 15.

    LeibundGut-Landmann S, Grosz O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 2007;8:630-638.

    Not in our library10.1038/ni1460

16. 16.
    DC activated via dectin‐1 convert Treg into IL‐17 producers · 2008

    No notice
17. 17.

    Ariizumi K, Shen GL, Shikano S, Ritter R, Zukas P, Edelbaum D, Morita A, et al. Cloning of a second dendritic cell-associated C-type lectin (Dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 2000;275:11957-11963.

    Not in our library10.1074/jbc.275.16.11957

18. 18.

    Fernandes MJ, Finnegan AA, Siracusa LD, Brenner C, Iscove NN, Calabretta B. Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 1999;59:2709-2717.

    Not in our library

19. 19.

    Taylor PR, Reid DM, Heinsbroek SE, Brown GD, Gordon S, Wong SY. Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. Eur. J. Immunol. 2005;35:2163-2174.

    Not in our library10.1002/eji.200425785

20. 20.

    Sato K, Yang XL, Yudate T, Chung JS, Wu J, Luby-Phelps K, Kimberly RP, et al. Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J. Biol. Chem. 2006;281:38854-38866.

    Not in our library10.1074/jbc.m606542200

21. 21.

    McGreal EP, Rosas M, Brown GD, Zamze S, Wong SY, Gordon S, Martinez-Pomares L, et al. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology. 2006;16:422-430.

    Not in our library10.1093/glycob/cwj077

22. 22.

    Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J. Immunol. 2009;182:1119-1128.

    Not in our library10.4049/jimmunol.182.2.1119

23. 23.

    Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, SjefVerbeek J, et al. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 2009;206:2037-2051.

    Not in our library10.1084/jem.20082818

24. 24.

    Conti HR, Shen F, Nayyar N, Stocum E, Sun JN, Lindemann MJ, Ho AW, et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 2009;206:299-311.

    Not in our library10.1084/jem.20081463

25. 25.

    Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 2004;190:624-631.

    Not in our library10.1086/422329

26. 26.

    Puel A, Daffinger R, Natividad A, Chrabieh M, Barcenas-Morales G, Picard C, Cobat A, et al. Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. 2010;207:291-297.

    Not in our library10.1084/jem.20091983

27. 27.

    Kisand K, Bøe Wolff AS, Podkrajsoek KT, Tserel L, Link M, Kisand KV, Ersvaer E, et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med. 2010;207:299-308.

    Not in our library10.1084/jem.20091669

28. 28.

    Puel A, Picard C, Cypowyj S, Lilic D, Abel L, Casanova J-L. Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? Curr. Opin. Immunol. 2010;22:467-474.

    Not in our library10.1016/j.coi.2010.06.009

29. 29.

    Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol. 2007;37:2695-2706.

    Not in our library10.1002/eji.200737409

30. 30.

    Conti HR, Gaffen SL. Host responses to Candida albicans: Th17 cells and mucosal candidiasis. Microbes Infect. 2010;12:518-527.

    Not in our library10.1016/j.micinf.2010.03.013

31. 31.

    Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, Sakuma M, Tateno H, et al. C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA. 2009;106:1897-1902.

    Not in our library10.1073/pnas.0805177106

32. 32.

    Brown GD. Sensing necrosis with Mincle. Nat. Immunol. 2008;9:1099-1100.

    Not in our library10.1038/ni1008-1099

33. 33.

    Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, et al. The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. J. Immunol. 2008;180:7404-7413.

    Not in our library10.4049/jimmunol.180.11.7404

34. 34.

    Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, et al. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 2009;206:2879-2888.

    Not in our library10.1084/jem.20091750

35. 35.

    Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, Agger EM, et al. Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate. J. Immunol. 2010;184:2756-2760.

    Not in our library10.4049/jimmunol.0904013

36. 36.

    Rogers NC, Slack EC, Edwards AD, Nolte MA, Schulz O, Schweighoffer E, Williams DL, et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity. 2005;22:507-517.

    Not in our library10.1016/j.immuni.2005.03.004

37. 37.

    Kerrigan AM, Brown GD. Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. Immunol. Rev. 2010;234:335-352.

    Not in our library10.1111/j.0105-2896.2009.00882.x

38. 38.

    Kelly EK, Wang L, Ivashkiv LB. Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages. J. Immunol. 2010;184:5545-5552.

    Not in our library10.4049/jimmunol.0901293

39. 39.

    Hise AG, Tomalka J, Ganesan S, Patel K, Hall BA, Brown GD, Fitzgerald KA. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe. 2009;5:487-497.

    Not in our library10.1016/j.chom.2009.05.002

40. 40.

    Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SCM, Geijtenbeek TBH. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-[kappa]B activation through Raf-1 and Syk. Nat. Immunol. 2009;10:203-213.

    Not in our library10.1038/ni.1692

Cited by papers we hold 5

• The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives · 2020
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• Human CARD9: A Critical Molecule of Fungal Immune Surveillance · 2018
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• CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System · 2015
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• Recent insights into structures and functions of C-type lectins in the immune system · 2015
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• Restoration of Pattern Recognition Receptor Costimulation to Treat Chromoblastomycosis, a Chronic Fungal Infection of the Skin · 2011
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