Progress of Actinidia chinensis Planch. root extract (acRoots) in cancer immunity
Lingyan Wang, Zheng Li, Miaomiao Zhang and 2 more
Clinical and Translational Discovery · 2023
doi:10.1002/ctd2.171 (opens in a new tab)
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Abstract
Abstract Actinidia chinensis Planch. root extract (acRoots) is a famous Chinese traditional medicine used in the treatment of a variety of diseases, such as tumours and cardiovascular diseases, etc. However, its therapeutic mechanisms remain unclear. In this review, the biological features of acRoots and its chemical compositions are explored, including polysaccharides, triterpenes, phenols, flavonoids and so on. The pathogenesis of cancer involves not only genetic factors but also the microenvironment. Different types of immune cells, such as T cells, macrophages and neutrophils, play an essential role in cancer development, and acRoots was found to take part in modulating cancer immunity. Therefore, this article summarises its role in cancer immunity and unmasks the potential underlying mechanisms by incorporating our research on cancer immunity.
Abstract licence: CC BY
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