Long non‐coding RNA modifies chromatin

Abstract

Common themes are emerging in the molecular mechanisms of long non‐coding RNA‐mediated gene repression. Long non‐coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of genes into silent compartments. The similarities suggest that these are fundamental processes of transcription regulation governed by lncRNAs. These findings have paved the way for analogous investigations on other lncRNAs and chromatin remodelling enzymes. Here we discuss these common mechanisms and provide our view on other molecules that warrant similar investigations. We also present our concepts on the possible mechanisms that may facilitate the exit of genes from the silencing domains and their potential therapeutic applications. Finally, we point to future areas of research and put forward our recommendations for improvements in resources and applications of existing technologies towards targeted outcomes in this active area of research.

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     Not in our library10.1038/nature09819

Cited by papers we hold 4

• Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme · 2018
  Not checked
• Long Noncoding RNAs in Imprinting and X Chromosome Inactivation · 2014
  Not checked
• The long non-coding RNA HOTAIR indicates a poor prognosis and promotes metastasis in non-small cell lung cancer · 2013
  No notice
• Cis and Trans Acting Factors Involved in Human Cytomegalovirus Experimental and Natural Latent Infection of CD14 (+) Monocytes and CD34 (+) Cells · 2013
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.