Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application

Abstract

We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non‐toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 44

1. 1.

   Lemire JA, Harrison JJ, Turner RJ. Nat. Rev. Microbiol. 2013;11:371-384.

   Not in our library10.1038/nrmicro3028

2. 2.

   Chernousova S, Epple M. Angew. Chem. 2013;125.

   Not in our library10.1002/anie.201205923

3. 3.

   Zhao Y, Tian Y, Cui Y, Liu W, Ma W, Jiang X. J. Am. Chem. Soc. 2010;132:12349-12356.

   Not in our library10.1021/ja1028843

4. 4.

   Zhao Y, Chen Z, Chen Y, Xu J, Li J, Jiang X. J. Am. Chem. Soc. 2013;135.

   Not in our library10.1021/ja4058635

5. 5.

   Zhao Y, Jiang X. Nanoscale. 2013;5.

   Not in our library10.1039/c3nr01990j

6. 6.

   Gu HW, Ho PL, Tong E, Wang L, Xu B. Nano Lett. 2003;3.

   Not in our library

7. 7.

   Lim B, Jiang M, Camargo PH, Cho EC, Tao J, Lu X, Zhu Y, Xia Y. Science. 2009;324:1302-1305.

   Not in our library10.1126/science.1170377

8. 8.

   Peng Z, Yang H. Nano Today. 2009;4.

   Not in our library

9. 9.

   Debe MK. Nature. 2012;486.

   Not in our library10.1038/nature11115

10. 10.

    Zhang Y, Cui X, Shi F, Deng Y. Chem. Rev. 2012;112.

    Not in our library10.1021/cr200260m

11. 11.

    Suntivich J, Xu Z, Carlton CE, Kim J, Han B, Lee SW, Bonnet N, Marzari N, Allard LF, Gasteiger HA, Hamad-Schifferli K, Shao-Horn Y. J. Am. Chem. Soc. 2013;135:7985-7991.

    Not in our library10.1021/ja402072r

12. 12.

    Ilayaraja N, Prabu N, Lakshminarasimhan N, Murugan P, Jeyakumar D. J. Mater. Chem. A. 2013;1.

    Not in our library

13. 13.

    Villa A, Veith GM, Prati L. Angew. Chem. 122.

    Not in our library10.1002/anie.201000762

14. 14.

    Brett GL, He Q, Hammond C, Miedziak PJ, Dimitratos N, Sankar M, Herzing AA, Conte M, Lopez-Sanchez JA, Kiely CJ, Knight DW, Taylor SH, Hutchings GJ. Angew. Chem. 2011;123.

    Not in our library10.1002/anie.201101772

15. 15.

    Schrinner M, Proch S, Mei Y, Kempe R, Miyajima N, Ballauff M. Adv. Mater. 2008;20:1928-1933.

    Not in our library

16. 16.

    Mokkath JH, Schwingenschlogl U. RSC Adv. 2013;3:15350-15353.

    Not in our library

17. 17.

    Mott D, Luo J, Njoki PN, Lin Y, Wang LY, Zhong CJ. Catal. Today. 2007;122.

    Not in our library

18. 18.

    Luo J, Njoki PN, Lin Y, Wang LY, Zhong CJ. Electrochem. Commun. 2006;8.

    Not in our library

19. 19.

    Ferrando R, Jellinek J, Johnston RL. Chem. Rev. 2008;108.

    Not in our library10.1021/cr040090g

20. 20.

    Comotti M, Della Pina C, Rossi M. J. Mol. Catal. A. 2006;251:89-92.

    Not in our library

21. 21.

    Wang D, Li Y. Adv. Mater. 2011;23:1044-1060.

    Not in our library10.1002/adma.201003695

22. 22.

    Alekshun MN, Levy SB. Cell. 2007;128:1037-1050.

    Not in our library10.1016/j.cell.2007.03.004

23. 23.

    Finberg RW, Moellering RC, Tally FP, Craig WA, Pankey GA, Dellinger EP, West MA, Joshi M, Linden PK, Rolston KV, Rotschafer JC, Rybak MJ. Clin. Infect. Dis. 2004;39:1314-1320.

    Not in our library10.1086/425009

24. 24.

    Pankey GA, Sabath LD. Clin. Infect. Dis. 2004;38.

    Not in our library10.1086/381972

25. 25.

    Zhao YY, Wang Z, Zhang W, Jiang XY. Nanoscale. 2011;2:2114-2119.

    Not in our library10.1039/c0nr00309c

26. 26.

    Stark WJ. Angew. Chem. 2010;123.

    Not in our library

27. 27.

    Limbach LK, Li Y, Grass RN, Brunner TJ, Hintermann MA, Muller M, Gunther D, Stark WJ. Environ. Sci. Technol. 2005;39.

    Not in our library10.1021/es051043o

28. 28.

    Pang M, Hu J, Zeng HC. J. Am. Chem. Soc. 2010;132:10771-10785.

    Not in our library10.1021/ja102105q

29. 29.

    Witte A, Wanner G, Sulzner M, Lubitz W. Arch. Microbiol. 1992;157:381-388.

    Not in our library10.1007/bf00248685

30. 30.

    Cui Y, Zhao Y, Tian Y, Zhang W, Lu X, Jiang X. Biomaterials. 2012;33:2327-2333.

    Not in our library10.1016/j.biomaterials.2011.11.057

31. 31.

    Lu P, Haagsma AC, Pham H, Maaskant JJ, Mol S, Lill H, Bald D. Antimicrob. Agents Chemother. 2011;55:5354-5357.

    Not in our library10.1128/aac.00507-11

32. 32.

    Hurdle JG, O’Neill AJ, Chopra I, Lee RE. Nat. Rev. Microbiol. 2011;9.

    Not in our library10.1038/nrmicro2474

33. 33.

    Kwon YD, Lee SY, Kim P. Biosci. Biotechnol. Biochem. 2008;72:1138-1141.

    Not in our library10.1271/bbb.70831

34. 34.

    Schneider DA, Gourse RL. J. Biol. Chem. 2004;279:8262-8268.

    Not in our library10.1074/jbc.m311996200

35. 35.

    Piccini A, Carta S, Tassi S, Lasiglie D, Fossati G, Rubartelli A. Proc. Natl. Acad. Sci. USA. 2008;105:8067-8072.

    Not in our library10.1073/pnas.0709684105

36. 36.

    Coutinho-Silva R, Ojcius DM. Microbes Infect. 2012;14.

    Not in our library10.1016/j.micinf.2012.05.009

37. 37.
    Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. · 2013

    Not checked
38. 38.

    Lammas DA, Stober C, Harvey CJ, Kendrick N, Panchalingam S, Kumararatne DS. Immunity. 1997;7:433-444.

    Not in our library10.1016/s1074-7613(00)80364-7

39. 39.

    Kohanski MA, Dwyer DJ, Hayete B, Lawrence CA, Collins JJ. Cell. 2007;130:797-810.

    Not in our library10.1016/j.cell.2007.06.049

40. 40.

    Natalio F, Andre R, Hartog AF, Stoll B, Jochum KP, Wever R, Tremel W. Nat. Nanotechnol. 2012;7:530-535.

    Not in our library10.1038/nnano.2012.91

41. 41.

    Limbach LK, Wick P, Manser P, Grass RN, Bruinink A, Stark WJ. Environ. Sci. Technol. 2007;41:4158-4163.

    Not in our library10.1021/es062629t

42. 42.

    Studer AM, Limbach LK, Van Duc L, Krumeich F, Athanassiou EK, Gerber LC, Moch H, Stark WJ. Toxicol. Lett. 2010;197:169-174.

    Not in our library10.1016/j.toxlet.2010.05.012

43. 43.

    Krulwich TA, Sachs G, Padan E. Nat. Rev. Microbiol. 2011;9:330-343.

    Not in our library10.1038/nrmicro2549

44. 44.

    Marrache S, Dhar S. Proc. Natl. Acad. Sci. USA. 2012;109:16288-16293.

    Not in our library10.1073/pnas.1210096109

Cited by papers we hold 6

• Surface-bound reactive oxygen species generating nanozymes for selective antibacterial action · 2021
  No notice
• A Comprehensive Review on the Synthesis, Characterization, and Biomedical Application of Platinum Nanoparticles · 2019
  No notice
• Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria · 2018
  No notice
• Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans” · 2018
  No notice
• Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer · 2017
  No notice
• Alternative Antimicrobial Approach: Nano-Antimicrobial Materials · 2015
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.